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When doing my background, I accidentaly got a little toluene on my index finger and didnt bother washing it off until I had finished working. The cap design is horrible on the tins, so the toluene pours all over the place and just runs down the side. It definitely dried the sh*t out of my finger and a thin layer of dead skin peeled off over the next few days, but this is because I didnt wash it off. I wouldnt be overly concerned about using gloves while painting the mixture on the backgrounds, only when working with the pure toluene. Or just be smart and wash your hands if you get some on yourself. My finger hasnt been dissolved to the bone or fallen off, just a little dry skin....