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Old 06-05-2009, 08:50 AM
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Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles.
Dis Aquat Organ. 2009 Feb 25;83(3):257-60
Batrachochytrium dendrobatidis (Bd) is a global threat to amphibian biodiversity. Current calls for conservation through captive breeding require that efficient and reliable antifungal treatments be developed for target species. Here we confirm that the antifungal itraconazole is an effective treatment for infection in larval Alytes muletensis (Mallorcan midwife toad). Exceptionally low doses applied as few as 7 times were effective at clearing infection from tadpoles for up to 28 days after treatment. However, we cannot recommend itraconazole as a treatment for this species as depigmentation of tadpoles was observed. Further research is required to determine the putative hepatotoxicity of this treatment.


Lack of Evidence for the Drought-linked Chytridiomycosis Hypothesis.
J Wildl Dis. 2009 Apr;45(2):537-41
A significant amount of recent research has focused on the potentially synergistic roles of climate change and disease in causing amphibian declines and extinctions. Herein I discuss the drought-linked chytridiomycosis hypothesis (DLCH), which states that prolonged or intensified dry seasons trigger or exacerbate epidemics of chytridiomycosis, a potentially lethal skin disease of amphibians caused by the chytrid fungus Batrachochytrium dendrobatidis. I demonstrate that the DLCH runs contrary to our knowledge of B. dendrobatidis physiology, biogeography, and host-parasite ecology and conclude that abnormally dry weather should actually favor amphibians by decreasing the prevalence, severity, and spread of chytridiomycosis.





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